How RSO Interacts With the Endocannabinoid System: Understanding Full-Spectrum Cannabis Oil

For many cannabis consumers, Rick Simpson Oil (RSO) is known as one of the most potent and full-bodied forms of cannabis extracts. At Rebel Roots Farms, we’re committed to helping people understand how different cannabis products interact with the body so they can make informed choices based on their personal preferences and wellness goals.
A common question we hear is:
How does RSO interact with the endocannabinoid system (ECS)?
This article explains the basics of the ECS, how cannabinoids engage with it, and why RSO offers a unique full-spectrum experience. This content is for educational purposes only and does not make medical or therapeutic claims.
What Is RSO?
RSO, or Rick Simpson Oil, is a full-extract cannabis oil made using the whole plant. It captures a broad spectrum of cannabinoids, terpenes, and other plant compounds, making it a popular choice for those who prefer a robust, full-spectrum cannabis profile.
RSO typically contains:
- High levels of THC
- A range of minor cannabinoids
- Naturally occurring terpenes
- Other whole-plant compounds
This gives RSO its reputation for depth, richness, and intensity.
What Is the Endocannabinoid System?
The endocannabinoid system (ECS) is a biological network present in all humans. Researchers believe it plays a role in maintaining internal balance and helping the body adapt to various inputs.
The ECS includes:
- Endocannabinoids made naturally by the body
- Cannabinoid receptors, mainly CB1 and CB2
- Enzymes that break down endocannabinoids
Cannabis-derived cannabinoids interact with this system, which may help explain why cannabis can produce different effects for different individuals.
How RSO Interacts With the ECS
1. THC and CB1 Receptors
RSO is typically high in THC, a cannabinoid known to bind to CB1 receptors, which are found mostly in the central nervous system. This interaction contributes to the intensity and characteristics of the experience many people report with RSO.
2. Minor Cannabinoids and CB2 Receptors
RSO also contains minor cannabinoids such as CBD, CBG, CBC, and CBN. These compounds may interact with CB2 receptors, which are found primarily in immune-related tissues. This adds to the overall full-spectrum profile of the oil.
3. Full-Spectrum Experiences and the Entourage Effect
The “entourage effect” is a term used to describe how cannabinoids, terpenes, and other plant molecules may influence one another. While research is ongoing, many cannabis consumers report that full-spectrum products like RSO feel more layered or nuanced compared to products containing a single isolated compound.
4. Terpenes Add to the Sensory Profile
Terpenes such as myrcene, caryophyllene, and limonene naturally occur in cannabis and contribute to its aroma and flavor. These compounds may also influence how individuals perceive the overall experience when using RSO.
5. Whole-Plant Oil Offers a Distinct User Experience
Because RSO retains a wide range of plant compounds, many users describe the effects as more full-bodied or longer lasting. Experiences vary significantly from person to person, and RSO’s high potency means consumers typically start with very small servings.
Why RSO May Feel Different Than Other Cannabis Products
RSO is often chosen by people who want:
- A high-potency option
- A full-spectrum cannabis extract
- A more complex or concentrated sensory experience
- A product that can be taken in small amounts
Individual experiences will vary based on tolerance, body chemistry, and consumption method.
Is RSO Right for You?
People often explore RSO when they are interested in a more concentrated, full-spectrum cannabis option. Because of its potency, it is recommended to start with a very small amount, often described as the size of a grain of rice.
Rebel Roots Farms encourages responsible use of cannabis and compliance with all local laws. Anyone with questions about cannabis and personal health should consult a qualified healthcare professional.
Final Thoughts
RSO offers a distinctive way to experience the full complexity of the cannabis plant. By interacting with the endocannabinoid system, it provides a full-spectrum profile that many consumers find appealing.
At Rebel Roots Farms, we value transparency, education, and a grounded approach to cannabis, and RSO remains one of the most notable expressions of whole-plant cannabis.



